猫脑脊液中发现的5-羟吲哚乙酸由大脑皮层产生的证据。
Evidence for the contribution by the cerebral cortex to 5-hydroxyindoleacetic acid found in the cerebrospinal fluid of cats.
作者信息
Min-Chu L, Mackenna B R, Watt J A
出版信息
Brain Res. 1981 Mar 23;209(1):235-9. doi: 10.1016/0006-8993(81)91187-2.
PMID:6163510
Abstract
Perfusion of artificial CSF from a lateral ventricle to the cerebral cortical subarachnoid space in anaesthetized cats was used to study the contribution of the cerebral cortex to the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in CSF. The technique did not cause rupture of the meninges. The use of [14C]5-HIAA and of probenecid suggested that there was a contribution and also a transport mechanism similar to that in the choroid plexus.
摘要
在麻醉猫中，通过将人工脑脊液从侧脑室灌注至大脑皮质蛛网膜下腔，来研究大脑皮质对脑脊液中5-羟吲哚乙酸（5-HIAA）浓度的影响。该技术不会导致脑膜破裂。使用[14C]5-HIAA和丙磺舒表明，存在一种类似于脉络丛中的作用及转运机制。
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