Van der Poel F W, Van Praag H M, Korf J
Psychopharmacology (Berl). 1977 Mar 23;52(1):35-40. doi: 10.1007/BF00426597.
The location of probenecid-sensitive elimination mechanisms of monoamine metabolites from the cerebrospinal fluid of the cat was determined with ventriculo-cisternal or ventriculo-lumbar perfusion techniques. These techniques were described in detail. Levels of endogenous homovanillic acid and 5-hydroxyindoleacetic acid were assayed in the perfusate. Probenecid administration induced the most marked increase of the levels of the monoamine metabolites in the ventriculo-lumbar perfusates. It was concluded that probenecid blocked the transport of both metabolites from the spinal subarachnoid space.
采用脑室-脑池或脑室-腰段灌注技术，确定了猫脑脊液中对丙磺舒敏感的单胺代谢产物清除机制的位置。这些技术已详细描述。测定灌注液中内源性高香草酸和5-羟吲哚乙酸的水平。丙磺舒给药导致脑室-腰段灌注液中单胺代谢产物水平最显著升高。得出的结论是，丙磺舒阻断了两种代谢产物从脊髓蛛网膜下腔的转运。
