Kemp J D, Madri J A
Eur J Immunol. 1981 Feb;11(2):90-4. doi: 10.1002/eji.1830110205.
The genetic influences on the specific IgG antibody response to helical antigenic determinants of native soluble type III and V (AB2) human collagen have been studied in mice. H-2-linked Ir genes have been detected for each of these collagens, as have background effects. The alleles controlling high antibody responses can be distinguished from those previously described for bovine collagen type I and type I propeptide. Apparent two-gene complementation in the response to type V (AB2) may indicate that this antigen will be a useful probe in further studies of the complex nature of antigen presentation for T cell recognition. The present studies may facilitate the production of specific, high-affinity monoclonal antibodies for the human collagens which, in turn, will facilitate the study of connective tissue biology and pathology.
在小鼠中研究了遗传因素对针对天然可溶性III型和V型（AB2）人胶原蛋白螺旋抗原决定簇的特异性IgG抗体反应的影响。已检测到与H-2连锁的Ir基因以及背景效应与这些胶原蛋白中的每一种相关。控制高抗体反应的等位基因可与先前描述的I型牛胶原蛋白和I型前肽的等位基因区分开来。对V型（AB2）胶原蛋白反应中明显的双基因互补可能表明，该抗原将成为进一步研究T细胞识别抗原呈递复杂性质的有用探针。本研究可能有助于生产针对人胶原蛋白的特异性、高亲和力单克隆抗体，这反过来又将有助于结缔组织生物学和病理学的研究。
