Franke H, Gronow G, Petersen K
Curr Probl Clin Biochem. 1977;8:424-34.
The influence of glucagon on renal function and hemodynamics was studied on isolated perfused rat kidneys. During perfusion with solutions containing no vasoactive substances glucagon increased total renal perfusion flow, while the GFR remained unchanged. The autoregulation of blood flow under these conditions was completely abolished. Na-excretion was slightly reduced under the action of glucagon, due to an increased fractional Na-reabsorption. However, increased fractional Na-reabsorption was not due to a direct influence of glucagon on tubular transport mechanism as comparison of TNa at identical Na-loads demonstrated. In presence of angiotensin II renal perfusion flow was markedly reduced and doubled almost after starting glucagon infusion. GFR under these conditions rose by about 100%. It is concluded from the results that changes of kidney function following glucagon infusion are mainly due to a reduced vascular resistance.
在离体灌注的大鼠肾脏上研究了胰高血糖素对肾功能和血流动力学的影响。在用不含血管活性物质的溶液灌注期间，胰高血糖素增加了肾脏的总灌注流量，而肾小球滤过率（GFR）保持不变。在这些条件下，血流的自动调节完全被消除。由于钠重吸收分数增加，在胰高血糖素作用下钠排泄略有减少。然而，钠重吸收分数增加并非由于胰高血糖素对肾小管转运机制的直接影响，因为在相同钠负荷下对总钠（TNa）的比较表明了这一点。在存在血管紧张素II的情况下，肾脏灌注流量明显降低，几乎在开始输注胰高血糖素后增加了一倍。在这些条件下，GFR上升了约100%。从结果得出结论，输注胰高血糖素后肾功能的变化主要是由于血管阻力降低。
