Rhoades R W
J Comp Neurol. 1981 Apr 10;197(3):425-45. doi: 10.1002/cne.901970306.
Electrophysiological methods were employed to determine whether or not partial visual cortical lesions in neonatal (7--11-day) hamster produced large scotomas in the cortical visual representation. In cases where such scotomas were present electrophoretic deposits of radioactive amino acids in the visually responsive "cortical remnant" of the damaged hemisphere resulted in labelling throughout the lower portion of the stratum griseum superficiale and the stratum opticum of the ipsilateral superior colliculus. No differential labeling of the part of the colliculus which was topographically matched with the remaining visual representation in the cortical remnant was observed. In normal hamsters relatively localized, visual cortical deposits of radioactive amino acids resulted in superficial layer labeling only in portions of the colliculus which corresponded to the locus of the cortical deposit. In a similar fashion, small lesions at physiologically defined loci in the cortical remnant produced degeneration throughout most of the superficial tectal laminae, but a more restricted "focus" of denser degeneration was also visible in these cases. The position of this focus in the colliculus for a given cortical lesion varied with the nature of the visual map in the cortical remnant. In several additional neonatally brain-damaged hamsters large lesions of the visual cortex in the intact hemisphere were combined with radioactive amino acid deposits in the cortical remnant to determine whether or not axons from the crossed corticocollicular pathway previously demonstrated in such hamsters were intermingled with fibers from the ipsilateral corticotectal projection. In alternate sections processed for autoradiography or by the Fink-Heimer ('67) method autoradiographic label and degeneration argyrophilia were both observed in the medical part of the colliculus ipsilateral to the neonatal cortical lesion.
采用电生理方法来确定新生（7 - 11日龄）仓鼠的部分视皮层损伤是否会在皮层视觉表征中产生大的盲点。在存在此类盲点的情况下，将放射性氨基酸电泳沉积到受损半球有视觉反应的“皮层残余”中，结果导致同侧上丘浅层灰质下部和视层全程被标记。未观察到上丘中与皮层残余中其余视觉表征在地形上匹配的部分有差异标记。在正常仓鼠中，放射性氨基酸相对局限的视皮层沉积仅导致上丘中与皮层沉积部位相对应的部分浅层被标记。以类似的方式，皮层残余中生理定义位点的小损伤导致大部分浅层顶盖板层发生退变，但在这些情况下也可见到一个更局限的、退变更密集的“焦点”。对于给定的皮层损伤，该焦点在丘中的位置随皮层残余中视觉图谱的性质而变化。在另外几只新生脑损伤的仓鼠中，将完整半球的视皮层大损伤与皮层残余中的放射性氨基酸沉积相结合，以确定先前在此类仓鼠中证实的交叉皮质 - 丘系通路的轴突是否与同侧皮质 - 顶盖投射的纤维混合。在用于放射自显影或Fink - Heimer（1967年）方法处理的交替切片中，在新生皮层损伤同侧丘的内侧部分观察到放射自显影标记和退变嗜银性。
