Gimmel'farb G N, Gerasimov N M, Kleĭnerman V E, Khan N I
Vestn Khir Im I I Grek. 1980 Dec;125(12):12-6.
The histamine concentration was estimated in the mixed venous and arterial blood in 28 patients with mitral defects subjected to closed mitral commissurotomy under balanced anesthesia. The oxygen content was determined simultaneously and the amount of blood shunting in the lungs was calculated by the oxygen method. It was established that the amount of histamine in the mixed venous blood coming to lungs was increased in patients with high degree lung hypertension. The balanced anesthesia itself did not influence the histamine concentration in the blood. The cessation of anesthesia, however, is followed by increased histamine concentration in the blood of patients with high lung hypertension. The process of blood shunting in the lungs is not controlled by histamine.
对28例二尖瓣缺损患者在平衡麻醉下施行闭式二尖瓣交界分离术时，测定了混合静脉血和动脉血中的组胺浓度。同时测定了氧含量，并通过氧法计算了肺内的分流量。结果表明，高度肺动脉高压患者进入肺内的混合静脉血中组胺含量增加。平衡麻醉本身并不影响血液中的组胺浓度。然而，麻醉停止后，高度肺动脉高压患者血液中的组胺浓度会升高。肺内的血液分流过程不受组胺控制。
