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激素避孕药对脂质代谢参数的影响(作者译)

[Effects of hormonal contraceptives on parameters of lipid metabolism (author's transl)].

作者信息

Carol W, Klinger G

出版信息

Zentralbl Gynakol. 1980;102(22):1273-82.

PMID:6164181
Abstract

Constant rise of triglycerides and low but regular increase of phospholipid concentrations in serum were observed as a consequence of intake of single-phase hormonal contraceptives. This has been paralleled by inconstant, moderate rise in cholesterol. Those effects are likely to demonstrate dependence on oestrogen amounts of the preparations in question as well as on both quality and quantity of the progestagenic component. Rising concentrations of low density lipoproteins were recordable with regularity. However, variegated results so far have been obtained from studies into the behaviour of high-density lipoproteins. -The mechanism of origin of those alterations, which usually did not surpass normal limits, and their relevance to clinical practice are discussed.

摘要

观察到,服用单相激素避孕药会导致血清甘油三酯持续升高,磷脂浓度虽低但有规律地增加。与此同时,胆固醇有不稳定的中度升高。这些影响可能取决于所讨论制剂的雌激素含量以及孕激素成分的质量和数量。低密度脂蛋白浓度有规律地升高。然而,迄今为止,关于高密度脂蛋白行为的研究结果各不相同。本文讨论了这些通常未超过正常范围的变化的产生机制及其与临床实践的相关性。

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