人类肉瘤抗原S3的特性分析
Characterization of human sarcoma antigen S3.
作者信息
Sethi J K, Hirshaut Y
出版信息
Br J Cancer. 1981 Mar;43(3):261-6. doi: 10.1038/bjc.1981.43.
An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amounts of CEA and AFP there is no correlation between S3 antigen and the presence or amount of these known tumour-associated substances. S3 antibody can be fully absorbed with guinea-pig kidney but not boiled beef or SRBC. S3, therefore, is a heterophile substance which has not previously been identified. A seroepidemiological survey confirms that S3-antibody prevalence is significantly increased in persons with a wide variety of malignant disease, as well as in family members of patients with sarcoma.
一种人类肉瘤的共同抗原S3已得到进一步鉴定。它在抗原性上与人类血型物质A和B以及嗜异性抗原如福斯曼抗原、传染性单核细胞增多症抗原和血清病抗原不同。虽然S3抗原制剂可能含有少量癌胚抗原（CEA）和甲胎蛋白（AFP），但S3抗原与这些已知肿瘤相关物质的存在或含量之间没有相关性。S3抗体可被豚鼠肾完全吸收，但不能被煮沸的牛肉或绵羊红细胞吸收。因此，S3是一种以前未被鉴定的嗜异性物质。一项血清流行病学调查证实，在患有多种恶性疾病的人群以及肉瘤患者的家庭成员中，S3抗体的流行率显著增加。
Zotero 插件