Khaĭkina B I, Shilina V F, Ivanitskiĭ V A
Vopr Pitan. 1976 May-Jun(1):47-50.
Some aspects of the biogenic amines -- serotonin and histamine metabolism in rats and guinea pigs following introduction to them of pesticides of different chemical nature, viz. gamma-isomer of hexachlorcyclohexane (lindane) and dimethyldithiocarbamate zinc (zyram) were studied. These pesticides were found to dissimilarly affect the passage with urine of the principal serotonin metabolite -- 5-oxyindol-acetic acid. A short-term (2 days) introduction to rats of large doses (34 mg/kg) of lindane and a protracted (90 days) action of low doses (1.7 mg/kg) produce changes in the content of serotonin and of 5-oxyindol-acetic acid in the brain, liver and kidneys. In the blood of guinea pigs receiving for a lenthy time (120 days) small amounts (4 mg/kg) of zyram shifts in the histamine-histaminase-histaminopexy system were revealed, this pointing to the ability of this pesticide to provoke the state of sensitization.
研究了不同化学性质的农药，即六氯环己烷的γ异构体（林丹）和二甲基二硫代氨基甲酸锌（代森锌）作用于大鼠和豚鼠后，生物胺——血清素和组胺代谢的某些方面。发现这些农药对主要血清素代谢物——5-羟吲哚乙酸的尿排泄有不同影响。给大鼠短期（2天）大剂量（34毫克/千克）注射林丹以及低剂量（1.7毫克/千克）长期（90天）作用，会使大脑、肝脏和肾脏中血清素和5-羟吲哚乙酸的含量发生变化。在长时间（120天）接受少量（4毫克/千克）代森锌的豚鼠血液中，发现组胺-组胺酶-组胺结合蛋白系统发生了变化，这表明这种农药有引发致敏状态的能力。
