Israël L, Aguilera J, Breau J L
Nouv Presse Med. 1981 May 16;10(22):1817-8, 1823-4.
Eighty consecutive patients with measurable and assessable squamous cell carcinoma of the head or neck, lung, oesophagus and uterine cervix received one to four courses of combined bleomycin and cis-platinum treatment. Each course lasted 5 to 6 days during which bleomycin was administered by continuous intravenous infusion and cis-platinum was given daily. If there was no evidence of toxicity or progressive disease, courses were repeated every 3 weeks to a total bleomycin dose of 150 mg/m2. A 75% objective response rate was obtained, with one case of progressive disease and no prohibitive toxic reaction. These results suggest that cytostatic drugs with low bone marrow toxicity can be given for prolonged periods and throw some doubt on the alleged resistance of squamous cell carcinomas to chemotherapy.
80例头颈部、肺部、食管和子宫颈可测量且可评估的鳞状细胞癌患者接受了1至4个疗程的博来霉素和顺铂联合治疗。每个疗程持续5至6天，在此期间博来霉素持续静脉输注，顺铂每日给药。如果没有毒性或疾病进展的证据，每3周重复疗程，直至博来霉素总剂量达到150mg/m²。获得了75%的客观缓解率，有1例疾病进展，无严重毒性反应。这些结果表明，骨髓毒性低的细胞毒性药物可以长期给药，这对所谓的鳞状细胞癌对化疗的耐药性提出了一些质疑。
