Molthan L
Vox Sang. 1981 Feb;40(2):105-8. doi: 10.1111/j.1423-0410.1981.tb00678.x.
Because of the increasing use of type, screen and hold protocols and minimal surgical blood order protocols in transfusion services, a number of patients are receiving un-cross-matched blood in elective situations. There are many low-frequency red blood cell antigens which are lacking on reagent cells used for antibody screening procedures, and alloantibodies directed against these antigens are relatively common and occur in either natural or immune forms. A case of an intravascular hemolytic transfusion reaction resulting in death is reported. The patients had a naturally occurring anti-Vw+Mia and received 1 U of Vw+Mia-positive donor red cells. It is the 1st documented case of a hemolytic transfusion reaction due to this incompatibility. The potential threat of transfusion reactions due to low-frequency antigens must be recognized by the physicians who design type, screen and hold protocols and it has particular reference to the selection of possible recipients for whom the protocols are applied.
由于输血服务中血型鉴定、抗体筛查和按需输血方案以及最小化手术用血申请方案的使用日益增加，许多患者在择期手术情况下接受了未交叉配血的血液。有许多低频红细胞抗原在用于抗体筛查程序的试剂细胞上并不存在，针对这些抗原的同种抗体相对常见，且以天然或免疫形式出现。本文报告了一例因血管内溶血输血反应导致死亡的病例。该患者有天然存在的抗-Vw+Mia抗体，并接受了1单位Vw+Mia阳性供者红细胞。这是第一例有记录的因这种血型不匹配导致的溶血输血反应病例。设计血型鉴定、抗体筛查和按需输血方案的医生必须认识到低频抗原引起输血反应的潜在威胁，这尤其涉及到应用这些方案的可能受血者的选择。
