加拿大的镰状细胞性状。由于与α地中海贫血基因相互作用导致的血红蛋白S的三峰分布。
Sickle cell traits in Canada. Trimodal distribution of Hb S as a result of interaction with alpha-thalassaemia gene.
作者信息
Wong S C, Ali M A, Boyadjian S E
出版信息
Acta Haematol. 1981;65(3):157-63. doi: 10.1159/000207172.
PMID:6165216
Abstract
A trimodal distribution of the amounts of Hb S in 56 sickle cell heterozygotes was observed. The variable amounts of Hb S were directly related to the mean cell volume and the mean cell Hb and were a result of the difference in net synthesis of Hb S due to the presence of the alpha-thalassaemia. Double heterozygotes for the Hb S and alpha-thalassaemia-1 genes, besides having a lower amount of Hb S in the red blood cells, were found to have lower Hb and slightly elevated Hb A2 levels.
摘要
在56名镰状细胞杂合子中观察到了血红蛋白S（Hb S）含量的三峰分布。Hb S含量的变化与平均红细胞体积和平均红细胞血红蛋白直接相关，这是由于α地中海贫血的存在导致Hb S净合成差异的结果。Hb S和α地中海贫血-1基因的双重杂合子，除了红细胞中Hb S含量较低外，还发现其血红蛋白水平较低且Hb A2水平略有升高。
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