Dumont Y, Larose L, Morisset J, Poirier G G
Br J Pharmacol. 1981 Jun;73(2):347-53. doi: 10.1111/j.1476-5381.1981.tb10428.x.
1 The appearance of pancreatic muscarinic receptors during development has been measured by use of the specific ligand [3H]-quinuclidinyl benzilate ([3H]-QNB). 2 QNB binding sites are present in foetal pancreas; their maximal concentration is attained at the age of 30 days and a significant decrease is observed in one year old animals. 3 Affinity of [3H]-QNB for the muscarinic receptor does not change with age. 4 An evaluation of the pancreatic secretory response to a cholinoceptor agonist as a function of age indicates that the development of this response parallels that of the receptor population. 5 It is suggested that, at all ages from 3 days after birth onwards, the maximal secretory response of the exocrine pancreas to a cholinoceptor agonist mobilizes the same proportion of the total population of QNB binding sites.
利用特异性配体[3H]-喹核醇基苯甲酸酯（[3H]-QNB）测定了胰腺毒蕈碱受体在发育过程中的出现情况。
QNB结合位点存在于胎儿胰腺中；其最大浓度在30日龄时达到，在1岁动物中观察到显著下降。
[3H]-QNB对毒蕈碱受体的亲和力不随年龄变化。
对胆碱能受体激动剂的胰腺分泌反应随年龄变化的评估表明，这种反应的发育与受体群体的发育平行。
有人提出，从出生后3天起的所有年龄段，外分泌胰腺对胆碱能受体激动剂的最大分泌反应动员了相同比例的QNB结合位点总数。
