Pollock V E, Teasdale T, Stern J, Volavka J
Electroencephalogr Clin Neurophysiol. 1981 May;51(5):470-6. doi: 10.1016/0013-4694(81)90223-6.
A double blind, placebo controlled study was designed to assess transient caffeine effects on spontaneous and evoked brain activity in man. Twelve normal males received 200 mg caffeine citrate or placebo on separate occasions. EEG from left and right occipital regions was recorded in the absence of stimulation and during the response to sine wave modulated light (SML). The photic stimulation frequencies were 5, 10, 15, 18 and 24 c/sec. EEG power at frequencies corresponding to fundamental and selected harmonics of stimulation frequencies was obtained. The time course of response to SML was studied over a period of 2 min. Caffeine reduced the EEG power under resting conditions and during SML stimulation. This reduction was statistically significant at 10 and 15 c/sec. At 24 c/sec, caffeine reduced the fundamental SML response, but not the resting EEG power. Evaluation of the SML response time course did not reveal any consistent tendencies. It appears that the response is sustained in a stable way over the period of 2 min.
一项双盲、安慰剂对照研究旨在评估短暂摄入咖啡因对人体自发和诱发脑活动的影响。12名正常男性在不同时间分别接受200毫克柠檬酸咖啡因或安慰剂。在无刺激以及对正弦波调制光（SML）作出反应期间，记录左右枕叶区域的脑电图。光刺激频率为5、10、15、18和24赫兹。获取与刺激频率的基波和选定谐波相对应频率下的脑电图功率。在2分钟的时间段内研究对SML的反应时间进程。咖啡因降低了静息状态下以及SML刺激期间的脑电图功率。这种降低在10和15赫兹时具有统计学意义。在24赫兹时，咖啡因降低了SML的基本反应，但未降低静息脑电图功率。对SML反应时间进程的评估未发现任何一致的趋势。似乎在2分钟的时间段内反应以稳定的方式持续。
