Bucsics A, Lembeck F
Eur J Pharmacol. 1981 Apr 24;71(1):71-7. doi: 10.1016/0014-2999(81)90387-3.
The in vitro release of immunoreactive substance P (I-SP) by capsaicin and three congeners was studied on slices of rat spinal cord upper dorsal horn. Capsaicin and its congeners were all able to stimulate I-SP release, indicating that they act on chemosensitive primary afferents terminating in this region. A positive correlation was found between the I-SP releasing and pain-producing potencies of these compounds. This is in agreement with the concept that primary afferents containing substance P (SP) are involved in the transmission of nociceptive information.
在大鼠脊髓上背角切片上研究了辣椒素及其三种同系物对免疫反应性P物质（I-SP）的体外释放情况。辣椒素及其同系物均能刺激I-SP释放，表明它们作用于终止于该区域的化学敏感初级传入神经。发现这些化合物的I-SP释放能力与产生疼痛的能力之间呈正相关。这与含有P物质（SP）的初级传入神经参与伤害性信息传递的概念相符。
