• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

PHA刺激和未刺激的人外周血淋巴细胞中小核RNA的合成

Small nuclear RNAs synthesis in PHA-stimulated and nonstimulated human peripheral blood lymphocytes.

作者信息

Jaruzelska J, Stolzmann W M, Wiktorowicz K, Slomski R

出版信息

Mol Cell Biochem. 1981 Mar 27;35(3):183-9. doi: 10.1007/BF02357088.

DOI:10.1007/BF02357088
PMID:6165884
Abstract

Five fractions of small nuclear RNAs (snRNAs) were identified in nuclei of human peripheral blood lymphocytes. They have been designated as: H, G', D, C and A (nomenclature according to Weinberg) in order to decreasing electrophoretic mobility. Their synthesis was observed from the first day of treatment with mitogen and was continued with different intensity during four days of culture. In nonstimulated lymphocytes exclusively A and G' fractions were detected but no (14C)-uridine incorporation was observed.

摘要

在人外周血淋巴细胞的细胞核中鉴定出了五种小核RNA(snRNA)组分。为了按照电泳迁移率递减的顺序,它们被命名为:H、G'、D、C和A(根据温伯格的命名法)。从用促细胞分裂剂处理的第一天就观察到了它们的合成,并且在培养的四天中以不同强度持续进行。在未受刺激的淋巴细胞中仅检测到A和G'组分,但未观察到(14C)-尿苷掺入。

相似文献

1
Small nuclear RNAs synthesis in PHA-stimulated and nonstimulated human peripheral blood lymphocytes.PHA刺激和未刺激的人外周血淋巴细胞中小核RNA的合成
Mol Cell Biochem. 1981 Mar 27;35(3):183-9. doi: 10.1007/BF02357088.
2
Effect of malathion on nucleic acid synthesis in phytohemagglutinin-stimulated human lymphocytes.马拉硫磷对植物血凝素刺激的人淋巴细胞核酸合成的影响。
Hum Genet. 1980;56(2):189-94. doi: 10.1007/BF00295693.
3
Immuno-suppressive effect of human macrophages. II. Influence of macrophages on the kinetics of DNA, RNA and protein synthesis in PHA-stimulated lymphocytes.
Acta Pathol Microbiol Scand C. 1978 Aug;86C(4):187-92.
4
Cholinergic stimulation of RNA synthesis in rat lymphocytes.
Arch Immunol Ther Exp (Warsz). 1981;29(6):789-93.
5
Analysis of Gene Expression Changes in PHA-M Stimulated Lymphocytes - Unraveling PHA Activity as Prerequisite for Dicentric Chromosome Analysis.PHA 刺激的淋巴细胞基因表达变化分析——揭示 PHA 活性作为双着丝粒染色体分析前提。
Radiat Res. 2018 Jun;189(6):579-596. doi: 10.1667/RR14974.1. Epub 2018 Apr 3.
6
Autoradiographic detection of HPRT variants of human lymphocytes resistant to RNA synthesis inhibition.
Mutat Res. 1985 Mar;149(1):133-40. doi: 10.1016/0027-5107(85)90018-1.
7
[Role of terminal deoxyribonucleotidyl transferase in stimulating lymphocyte DNA synthesis as affected by PHA].[末端脱氧核苷酸转移酶在刺激淋巴细胞DNA合成中受PHA影响的作用]
Tsitologiia. 1983 Oct;25(10):1212-5.
8
The effect of sesquiterpene lactones on the synthesis of nucleic acid in cultures of human lymphocytes stimulated by phytohemagglutinin.倍半萜内酯对受植物血凝素刺激的人淋巴细胞培养物中核酸合成的影响。
Arch Immunol Ther Exp (Warsz). 1981;29(2):195-203.
9
Responses of chronic lymphocytic leukemic lymphocytes to increasing concentrations of phytohemagglutinin during short-term culture.短期培养期间慢性淋巴细胞白血病淋巴细胞对递增浓度植物血凝素的反应。
Int J Clin Pharmacol Ther Toxicol. 1982 Jun;20(6):265-7.
10
Effects of He-Ne laser irradiation on chromatin properties and synthesis of nucleic acids in human peripheral blood lymphocytes.氦氖激光照射对人外周血淋巴细胞染色质特性及核酸合成的影响。
Biomed Sci. 1991;2(2):121-6.

本文引用的文献

1
Are snRNPs involved in splicing?小核核糖核蛋白颗粒参与剪接过程吗?
Nature. 1980 Jan 10;283(5743):220-4. doi: 10.1038/283220a0.
2
Small molecular weight monodisperse nuclear RNA.小分子单分散核RNA
J Mol Biol. 1968 Dec;38(3):289-304. doi: 10.1016/0022-2836(68)90387-2.
3
Synthesis of 5S and 4S RNA in metaphase-arrested HeLa cells.处于中期停滞状态的海拉细胞中5S和4S RNA的合成。
Science. 1971 May 28;172(3986):947-9. doi: 10.1126/science.172.3986.947.
4
Low-molecular-weight nuclear RNAs.
Perspect Biol Med. 1971 Fall;15(1):117-39. doi: 10.1353/pbm.1971.0055.
5
Low molecular weight nuclear RNA in phytohemagglutinin-treated and untreated human lymphocytes.
Exp Cell Res. 1972 Feb;70(2):460-2. doi: 10.1016/0014-4827(72)90166-8.
6
Studies on low molecular weight RNA of chromatin. Effects of template activity of chick liver chromatin.
Biochim Biophys Acta. 1971 Jun 17;240(1):46-55. doi: 10.1016/0005-2787(71)90511-9.
7
The small molecular weight monodisperse nuclear RNA's in mitotic cells.有丝分裂细胞中的小分子单分散核RNA
Biochim Biophys Acta. 1971 Mar 11;232(2):306-13. doi: 10.1016/0005-2787(71)90583-1.
8
The determination of the molecular weight of ribonucleic acid by polyacrylamide-gel electrophresis. The effects of changes in conformation.通过聚丙烯酰胺凝胶电泳测定核糖核酸的分子量。构象变化的影响。
Biochem J. 1969 Jun;113(1):131-8. doi: 10.1042/bj1130131.
9
Metabolic studies on small molecular weight nuclear RNA components in human lymphocytes.人类淋巴细胞中小分子量核RNA成分的代谢研究。
Exp Cell Res. 1974 Mar 30;85(1):1-7. doi: 10.1016/0014-4827(74)90205-5.
10
Low molecular weight nuclear RNA in human lymphocytes. A comparison of PHA-treated and control cells.
Exp Cell Res. 1973 Dec;82(2):280-6. doi: 10.1016/0014-4827(73)90342-x.