Veronesi A, Barzan L, Magri M D, Tirelli U, Galligioni E, Trovò M G, Tumolo S, Comoretto R, Grigoletto E
Strahlentherapie. 1981 Apr;157(4):277-9.
Twenty-seven evaluable patients with advanced head and neck squamous carcinoma were treated with a polychemotherapeutic regimen described in 1975 by Price et al. Chemotherapy consisted of vincristine, adriamycin, bleomycin, methotrexate, 5-fluorouracil, hydroxyurea, 6-mercaptopurine and citrovorum factor administered sequentially. One complete remission, 4 partial remissions, 7 minor responses were obtained for a total of 12/77 (44%) objective responses. Toxicity was acceptable. The results obtained were not better than those observed with less complicated regimens administrable on an outpatient basis.
27例可评估的晚期头颈部鳞状细胞癌患者接受了Price等人于1975年描述的多药化疗方案治疗。化疗药物依次包括长春新碱、阿霉素、博来霉素、甲氨蝶呤、5-氟尿嘧啶、羟基脲、6-巯基嘌呤和亚叶酸钙。获得1例完全缓解、4例部分缓解、7例轻度缓解，客观缓解率总计为12/77（44%）。毒性反应可以接受。所获得的结果并不优于在门诊可施行的较简单方案所观察到的结果。
