Bogdan I, Cristea G, Coman S
Arch Exp Veterinarmed. 1981;35(2):223-30.
Inflammatory processes were provoked in 35 rats by subcutaneous implantation of sterile cotton-wool pads and treated five days by means of various antiphlogistic substances. The action of sodium salicylate (administered alone or in conjunction with gamma-globulin or with glucose) proved similar to that of prednisolone which was given as control substance. Human gamma-globulin exhibited neither anti-inflammatory nor pro-inflammatory effects. Experiments with twelve rabbits revealed that the pyretogenic potential of sodium nucleinate, one per cent (0.01 g/kg body weight) was stronger than that of animal charcoal or peptone. Yet, the two latter substances may be used, as well. The antipyretic effect of sodium salicylate was not as intensive but just as reliable as that of aminophenazone, when both preparations were applied to rabbits with induced fever. Concomitant administration of glucose is recommended to prevent development of undesired side-effects, such as giddiness or ataxia.
通过皮下植入无菌棉垫在35只大鼠中引发炎症过程，并使用各种抗炎物质进行了五天的治疗。水杨酸钠（单独给药或与γ-球蛋白或葡萄糖联合给药）的作用与作为对照物质给予的泼尼松龙相似。人γ-球蛋白既没有抗炎作用也没有促炎作用。对12只兔子进行的实验表明，1%（0.01 g/kg体重）的核酸钠的致热潜力比动物炭或蛋白胨更强。然而，后两种物质也可以使用。当将两种制剂应用于诱导发热的兔子时，水杨酸钠的解热作用不如氨基苯酮强烈，但同样可靠。建议同时给予葡萄糖以防止出现如头晕或共济失调等不良副作用。
