Billiau A, Heremans H, Ververken D, van Damme J, Carton H, de Somer P
Arch Virol. 1981;68(1):19-25. doi: 10.1007/BF01315163.
Preparations of human leukocyte (alpha) and fibroblast (beta) interferon were given intramuscularly to rabbits and monkeys, and circulating interferon was measured. In rabbits, but not in monkeys, a marked difference between the two interferons was noted in that higher titers of circulating antiviral activity were obtained with leukocyte than with fibroblast interferon. In mice, injected interperitoneally, a similar difference could be noted. However, levels of antiviral activity in homogenates of spleens and lungs did not differ between mice injected with either interferon. Fibroblast interferon that was injected intrathecally in monkeys was found to diffuse throughout the cerebrospinal canal and to reach the serum compartment. Some interferon could also be recovered from the pia mater surrounding the brain hemispheres, but none was found in the deeper layers of the brain.
将人白细胞（α）干扰素制剂和成纤维细胞（β）干扰素制剂分别肌肉注射给兔子和猴子，并检测循环中的干扰素。在兔子而非猴子中，发现两种干扰素存在显著差异，即白细胞干扰素比成纤维细胞干扰素产生更高的循环抗病毒活性滴度。在经腹腔注射的小鼠中也可观察到类似差异。然而，注射了任一干扰素的小鼠，其脾脏和肺匀浆中的抗病毒活性水平并无差异。在猴子中鞘内注射的成纤维细胞干扰素可扩散至整个脑脊管并进入血清区室。在大脑半球周围的软脑膜中也可回收一些干扰素，但在大脑深层未发现。
