聚硫酸乙烯酯（PVS）对逆转录酶的抑制作用。
Inhibition of reverse transcriptase by polyvinyl sulfate (PVS).
作者信息
Hallinan F M, Lee S H, Rozee K R
出版信息
Cancer Biochem Biophys. 1981;5(2):97-101.
PMID:6166365
Abstract
The effect of the ribonuclease inhibitor polyvinyl sulfate on the activity of retroviral DNA polymerase and terminal c transferase was examined. This substance was found to be a potent inhibitor of these enzymes by virtue of competition between the sulfated sidechains of the molecule and the template primer for a site on the enzyme. The significance of these findings in relation to searching for reverse transcriptase is discussed.
摘要
研究了核糖核酸酶抑制剂聚硫酸乙烯酯对逆转录病毒DNA聚合酶和末端转移酶活性的影响。由于该分子的硫酸化侧链与模板引物在酶上的一个位点存在竞争，发现这种物质是这些酶的有效抑制剂。讨论了这些发现与寻找逆转录酶的相关性。
相似文献
1
Inhibition of reverse transcriptase by polyvinyl sulfate (PVS).聚硫酸乙烯酯（PVS）对逆转录酶的抑制作用。
Cancer Biochem Biophys. 1981;5(2):97-101.
2
3
Suramin: a potent inhibitor of the reverse transcriptase of RNA tumor viruses.苏拉明：一种有效的RNA肿瘤病毒逆转录酶抑制剂。
Cancer Lett. 1979 Nov;8(1):9-22. doi: 10.1016/0304-3835(79)90017-x.
4
Isolation and partial characterization of the reverse transcriptases of Rauscher murine leukemia virus, simian sarcoma virus and RD-114 virus.劳氏鼠白血病病毒、猿猴肉瘤病毒和RD - 114病毒逆转录酶的分离及部分特性鉴定
Biochim Biophys Acta. 1980 Oct 17;609(3):483-91. doi: 10.1016/0005-2787(80)90122-7.
5
A competition immunoassay for characterizing the reverse transcriptase of mammalian RNA tumor viruses.一种用于鉴定哺乳动物RNA肿瘤病毒逆转录酶的竞争性免疫测定法。
Virology. 1978 Aug;89(1):95-101. doi: 10.1016/0042-6822(78)90043-0.
6
7
Binding of tRNA to reverse transcriptase of RNA tumor viruses.转运核糖核酸与RNA肿瘤病毒逆转录酶的结合。
J Virol. 1978 May;26(2):214-20. doi: 10.1128/JVI.26.2.214-220.1978.
8
Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain.莫洛尼鼠白血病病毒逆转录酶N端片段与核酸复合的晶体结构：模板引物与指状结构域结合的功能意义
J Mol Biol. 2000 Feb 18;296(2):613-32. doi: 10.1006/jmbi.1999.3477.
9
Phosphonoformate inhibits reverse transcriptase.膦甲酸抑制逆转录酶。
J Gen Virol. 1979 Nov;45(2):273-81. doi: 10.1099/0022-1317-45-2-273.
10
Polycitone A, a novel and potent general inhibitor of retroviral reverse transcriptases and cellular DNA polymerases.多西酮A，一种新型强效逆转录病毒逆转录酶和细胞DNA聚合酶的通用抑制剂。
Biochem J. 1999 Nov 15;344 Pt 1(Pt 1):85-92.
引用本文的文献
1
Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor, sulfated polysaccharides extracted from sea algae.从海藻中提取的一种禽成髓细胞瘤病毒和人类免疫缺陷病毒逆转录酶抑制剂——硫酸化多糖的纯化与特性分析
Antimicrob Agents Chemother. 1987 Oct;31(10):1524-8. doi: 10.1128/AAC.31.10.1524.
Zotero 插件