Hallinan F M, Lee S H, Rozee K R
Cancer Biochem Biophys. 1981;5(2):97-101.
The effect of the ribonuclease inhibitor polyvinyl sulfate on the activity of retroviral DNA polymerase and terminal c transferase was examined. This substance was found to be a potent inhibitor of these enzymes by virtue of competition between the sulfated sidechains of the molecule and the template primer for a site on the enzyme. The significance of these findings in relation to searching for reverse transcriptase is discussed.
研究了核糖核酸酶抑制剂聚硫酸乙烯酯对逆转录病毒DNA聚合酶和末端转移酶活性的影响。由于该分子的硫酸化侧链与模板引物在酶上的一个位点存在竞争，发现这种物质是这些酶的有效抑制剂。讨论了这些发现与寻找逆转录酶的相关性。
