Aizawa T, Yamada T
Clin Exp Pharmacol Physiol. 1981 May-Jun;8(3):215-25. doi: 10.1111/j.1440-1681.1981.tb00154.x.
In an attempt to study the effects of thyroid hormones, antithyroid drugs and iodide on the conversion of thyroxine (T4) to triiodothyronine (T3), the liver was obtained from normal, hypothyroid and hyperthyroid rats treated with T4 or T3 . T4 was incubated with liver homogenates and generated T3 was measured. 1. The conversion of T4 to T3 was less in the liver homogenates from thyroidectomized, methylmercaptoimidazole (MMI)-treated and propylthiouracil (PTU)-treated rats. The magnitude of decrease was the same in thyroidectomized and MMI-treated rats, but was greater in PTU-treated rats. 2. Administration of T4 and T3 to thyroidectomized and MMI-treated rats restored the converting activity. When excess T4 was administered, the converting activity was above normal. In contrast, administration of graded doses of T4 failed to restore the converting activity of the liver from PTU-treated rats. 3. In vitro addition of MMI failed to affect converting activity of the liver, but addition of excess iodide and PTU significantly depressed it.
为了研究甲状腺激素、抗甲状腺药物和碘化物对甲状腺素（T4）转化为三碘甲状腺原氨酸（T3）的影响，从用T4或T3处理的正常、甲状腺功能减退和甲状腺功能亢进大鼠获取肝脏。将T4与肝脏匀浆一起孵育，并测定生成的T3。1. 在甲状腺切除、用甲巯咪唑（MMI）处理和用丙硫氧嘧啶（PTU）处理的大鼠的肝脏匀浆中，T4向T3的转化较少。甲状腺切除和MMI处理的大鼠中降低的幅度相同，但PTU处理的大鼠中降低幅度更大。2. 给甲状腺切除和MMI处理的大鼠给予T4和T3可恢复转化活性。当给予过量T4时，转化活性高于正常水平。相比之下，给予不同剂量的T4未能恢复PTU处理大鼠肝脏的转化活性。3. 在体外添加MMI未能影响肝脏的转化活性，但添加过量碘化物和PTU会显著降低其活性。
