Lay J P, Klein W, Korte F, Richter E
J Environ Sci Health B. 1981;16(3):227-38. doi: 10.1080/03601238109372254.
beta-Hexachlorocyclohexane-14C (1.5 ppm) was administered in the diet to rats for one week. During the elimination phase three therapeutic agents were fed to enhance the clearance. Renal and fecal excreted radioactive products were collected for 8 weeks and extracted. Although significant differences in the total excreted amount of radioactivity were registered between controls and treated rats, there were no quantitative differences in the extractability of the excreta and no differences in the chemical nature of metabolites found. Radioactivity in urine consisted to 100% of conversion products, about 30% of which were unextractable residues. In the organic soluble fraction the 2,4,6-trichlorophenol was the major metabolite in urine and the only metabolite detected in feces. Minor conversion products of beta-HCH in urine were a trichlorohydroxyme-thoxybenzene, a dichlorophenol and a trace of a tetrachlorocyclohexane-isomer.
将含14C标记的β-六氯环己烷（1.5 ppm）添加到大鼠的饮食中，持续一周。在消除阶段，投喂三种治疗剂以促进清除。收集肾脏和粪便中排出的放射性产物，为期8周，并进行提取。虽然对照大鼠和接受治疗的大鼠之间在放射性总排泄量上存在显著差异，但排泄物的可提取性没有定量差异，并且所发现的代谢物的化学性质也没有差异。尿液中的放射性全部由转化产物组成，其中约30%是不可提取的残留物。在有机可溶部分中，2,4,6-三氯苯酚是尿液中的主要代谢物，也是粪便中检测到的唯一代谢物。尿液中β-六氯环己烷的次要转化产物是三氯羟基甲氧基苯、二氯苯酚和微量的四氯环己烷异构体。
