对旋毛形线虫这种寄生性线虫阶段特异性表面抗原的免疫反应。
Immune response to stage-specific surface antigens of the parasitic nematode Trichinella spiralis.
作者信息
Philipp M, Taylor P M, Parkhouse R M, Ogilvie B M
出版信息
J Exp Med. 1981 Jul 1;154(1):210-5. doi: 10.1084/jem.154.1.210.
Rats were infected with the nematode Trichinella spiralis and the primary serum antibody response to antigenic surface proteins of infective larvae, intestinal worms, and newborn larvae was studies. 1 wk after infection, the sera contained antibodies to surface antigens of both infective larvae and intestinal worms. These early sera, however, failed to react with newborn larvae surface antigens. In addition, adsorption of sera with living intestinal worms or infective larvae removed antibodies to surface antigens of the homologous stage only. Finally, the time-course of appearance of antibodies that mediate eosinophil adherence to the surface of each stage of the parasite. We concluded that in a primary infection in rats, the surface proteins of T. spiralis used in this study are antigenically stage specific. Furthermore, they could be targets for the stage-specific, antibody-dependent eosinophil-mediated destruction of this parasite, known to occur in vitro.
将大鼠感染旋毛虫线虫，并研究其对感染性幼虫、肠道蠕虫和新生幼虫抗原性表面蛋白的初次血清抗体反应。感染后1周，血清中含有针对感染性幼虫和肠道蠕虫表面抗原的抗体。然而，这些早期血清未能与新生幼虫表面抗原发生反应。此外，用活的肠道蠕虫或感染性幼虫吸附血清只会去除针对同源阶段表面抗原的抗体。最后，研究了介导嗜酸性粒细胞粘附于寄生虫各阶段表面的抗体出现的时间进程。我们得出结论，在大鼠的初次感染中，本研究中使用的旋毛虫表面蛋白在抗原上具有阶段特异性。此外，它们可能是这种寄生虫在体外已知发生的阶段特异性、抗体依赖性嗜酸性粒细胞介导破坏的靶点。
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