Glasgow L A, Kern E R
J Natl Cancer Inst. 1981 Jul;67(1):207-12.
The iv inoculation of a suspension of osteogenic sarcoma cells induced metastatic tumor nodules in the lungs of C57BL/6 mice. The administration of 50,000-100,000 U of interferon daily for 7 days strikingly reduced the tumor mass in the lung and the number of tumor nodules present in histopathologic sections when the interferon treatment was initiated immediately after tumor cell inoculation. In some animals the development of any detectable metastatic lesion was completely prevented. Extending the therapy form 7 days to 21 days failed to improve the protective effect. Interferon therapy delayed until 7 days after tumor cell inoculation had no effect. These findings indicate the effectiveness of exogenous interferon in this murine osteogenic sarcoma model when interferon treatment is initiated within 1 hour of tumor cell inoculation, but not when it is delayed until tumor nodules are established in the lungs.
将成骨肉瘤细胞悬液经静脉接种可在C57BL/6小鼠肺部诱导出转移性肿瘤结节。在肿瘤细胞接种后立即开始，每天给予50,000 - 100,000单位干扰素，持续7天，显著减少了肺部的肿瘤块以及组织病理学切片中肿瘤结节的数量。在一些动物中，完全预防了任何可检测到的转移性病变的发生。将治疗时间从7天延长至21天未能提高保护效果。将干扰素治疗推迟到肿瘤细胞接种后7天才开始则没有效果。这些发现表明，在该小鼠成骨肉瘤模型中，当在肿瘤细胞接种后1小时内开始干扰素治疗时，外源性干扰素有效，但当推迟到肺部肿瘤结节形成后则无效。
