O'Hara N, Ono H, Oguro K, Hashimoto K
J Cardiovasc Pharmacol. 1981 Mar-Apr;3(2):251-68. doi: 10.1097/00005344-198103000-00004.
We compared the vasodilator effects of perhexiline on canine coronary, femoral, renal, and mesenteric arteries with those of glyceryl trinitrate and verapamil. Intravenous perhexiline produced vasodilation of all four vascular beds and decreased peripheral vascular resistance. High doses of perhexiline sometimes increased peripheral vascular resistance and reduced peripheral blood flow. This increase in resistance was abolished by hexamethonium. Intra-arterial perhexiline caused dose-dependent dilation in all four vascular beds without selectivity for the coronary circulation. Neither the autonomic nervous system nor inhibition of adenosine deaminase was involved in the vasodilator action of perhexiline. Perhexiline abolished renal blood flow autoregulation, an effect which was reversed by simultaneous administration of CaCl2. These results suggest that the vasodilator effect of perhexiline is mediated by its Ca2+-antagonistic activity. However, some differences in its effects from those of other Ca2+-antagonists remain to be clarified.
我们将哌克昔林对犬冠状动脉、股动脉、肾动脉和肠系膜动脉的血管舒张作用与硝酸甘油和维拉帕米的作用进行了比较。静脉注射哌克昔林可使所有这四个血管床血管舒张，并降低外周血管阻力。高剂量的哌克昔林有时会增加外周血管阻力并减少外周血流量。六甲铵可消除这种阻力增加。动脉内注射哌克昔林可使所有四个血管床产生剂量依赖性舒张，对冠脉循环无选择性。哌克昔林的血管舒张作用既不涉及自主神经系统，也不涉及腺苷脱氨酶的抑制。哌克昔林消除了肾血流自身调节，同时给予氯化钙可逆转这一效应。这些结果表明，哌克昔林的血管舒张作用是由其钙拮抗活性介导的。然而，其与其他钙拮抗剂作用的一些差异仍有待阐明。
