一种新型卡前列素衍生物（ZK 36 374）的抗血小板和心血管作用——在体外与前列环素（PGI2）等效。 - Suppr

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超能文献

The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374)--equipotent to PGI2 in vitro.

作者信息

Schrör K, Darius H, Matzky R, Ohlendorf R

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1981 Jun;316(3):252-5. doi: 10.1007/BF00505658.

DOI:10.1007/BF00505658

PMID:6166877

Abstract

摘要

相似文献

The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374)--equipotent to PGI2 in vitro.一种新型卡前列素衍生物（ZK 36 374）的抗血小板和心血管作用——在体外与前列环素（PGI2）等效。

Naunyn Schmiedebergs Arch Pharmacol. 1981 Jun;316(3):252-5. doi: 10.1007/BF00505658.

Dissociation of antiplatelet effects from myocardial cytoprotective activity during acute myocardial ischemia in cats by a new carbacyclin derivative (ZK 36 375).

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Comparison of the vasodepressor action of ZK 36 374, a stable prostacyclin derivative, PGI2 and PGE1 with their effect on platelet aggregation and bleeding time in rats.稳定的前列环素衍生物ZK 36374、前列环素（PGI2）和前列腺素E1（PGE1）的血管降压作用及其对大鼠血小板聚集和出血时间影响的比较

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The relative activity of prostacyclin (PGI2) and a stable analogue 6beta-PGI1 on the gastrointestinal and cardiovascular systems.

J Pharm Pharmacol. 1978 Sep;30(9):597-9. doi: 10.1111/j.2042-7158.1978.tb13338.x.

dl-9a-Deoxy-9a-methylene-PGI2 (a stable prostacyclin derivative): preliminary pharmacological data.

Prostaglandins Med. 1980 Aug;5(2):131-9. doi: 10.1016/0161-4630(80)90100-7.

Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors.功能和配体结合研究表明血小板前列环素受体存在异质性。

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Inhibitory effects of ZK 36374, a stable prostacyclin analogue, on adhesion of rabbit platelets to damaged aorta and serotonin release by adherent platelets.稳定前列环素类似物ZK 36374对兔血小板与受损主动脉黏附及黏附血小板释放5-羟色胺的抑制作用

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(5Z)-carbacyclin displays agonist-antagonist properties on prostacyclin-receptors in platelets and vascular myocytes.（5Z）-卡前列环素在血小板和血管平滑肌细胞的前列环素受体上表现出激动剂-拮抗剂特性。

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Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets.

Prog Clin Biol Res. 1989;301:365-9.

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本文引用的文献

Prevention of infarction-induced decrease in circulating platelet count by prostacyclin.前列环素预防梗死引起的循环血小板计数降低。

Thromb Res. 1980;19(4-5):447-53. doi: 10.1016/0049-3848(80)90017-1.

Prostacyclin infusion during cardiopulmonary bypass in man.人体体外循环期间输注前列环素。

Thromb Res. 1980;19(1-2):267-70. doi: 10.1016/0049-3848(80)90426-0.

Prostacyclin deficiency in haemolytic-uraemic syndrome.溶血尿毒综合征中的前列环素缺乏症。

Br Med J. 1980 Jul 26;281(6235):271. doi: 10.1136/bmj.281.6235.271.

Identification of the major metabolite of prostacyclin and 6-ketoprostaglandin F1 alpha in man.人体内前列环素和6-酮前列腺素F1α主要代谢物的鉴定。

Biochim Biophys Acta. 1980 Aug 11;619(2):207-13. doi: 10.1016/0005-2760(80)90069-7.

6-keto PGE1: a possible metabolite of prostacyclin having platelet antiaggregatory effects.6-酮前列环素E1：一种可能具有血小板抗聚集作用的前列环素代谢产物。

Hypertension. 1980 Jul-Aug;2(4):524-8. doi: 10.1161/01.hyp.2.4.524.

Comparison in anesthetized dogs of the anti-aggregatory and hemodynamic effects of prostacyclin and a chemically stable prostacyclin analog, 6a-carba-PGI2 (carbacyclin).在麻醉犬中比较前列环素和一种化学稳定的前列环素类似物6a-卡前列素（卡巴前列素）的抗聚集作用和血流动力学效应。

Prostaglandins. 1980 Apr;19(4):629-43. doi: 10.1016/s0090-6980(80)80011-6.

Carbacyclin--a potent stable prostacyclin analogue for the inhibition of platelet aggregation.卡巴前列素——一种用于抑制血小板聚集的强效稳定前列环素类似物。

Prostaglandins. 1980 Apr;19(4):605-27. doi: 10.1016/s0090-6980(80)80010-4.

10,10-Difluoro-13-dehydroprostacyclin: a chemically and metabolically stabilized potent prostacyclin.

J Med Chem. 1980 Mar;23(3):234-7. doi: 10.1021/jm00177a003.

dl-9a-Deoxy-9a-methylene-PGI2 (a stable prostacyclin derivative): preliminary pharmacological data.

Prostaglandins Med. 1980 Aug;5(2):131-9. doi: 10.1016/0161-4630(80)90100-7.

Prostacyclin-induced coronary vasodilation. Interactions with adenosine, cyclic AMP and energy charge in the rat heart in vitro.

Eur J Pharmacol. 1980 Jun 27;64(4):341-8. doi: 10.1016/0014-2999(80)90242-3.

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