Starkey P M
Acta Biol Med Ger. 1977;36(11-12):1549-54.
The degradation of collagen in a number of inflammatory diseases is associated with infiltration of the tissues by neutrophil leucocytes. The neutrophil serine proteinases, elastase and cathepsin G, solubilize type II collagen from articular cartilage by an attack on the terminal peptides, destroying the inter- and intra-molecular crosslinks. Both enzymes also solubilize type IV collagen from kidney basement membrane. Elastase attacks the terminal peptides of type I collagen of tendon, cornea and skin, and also attacks the helical region of type I skin collagen. It seems probable that the neutrophil proteinases play an important role in collagen degradation in vivo in a variety of pathological conditions.
在一些炎症性疾病中，胶原蛋白的降解与中性粒细胞浸润组织有关。中性粒细胞丝氨酸蛋白酶、弹性蛋白酶和组织蛋白酶G通过攻击末端肽，破坏分子间和分子内交联，使关节软骨中的II型胶原蛋白溶解。这两种酶还能使肾基底膜中的IV型胶原蛋白溶解。弹性蛋白酶攻击肌腱、角膜和皮肤中I型胶原蛋白的末端肽，也攻击皮肤I型胶原蛋白的螺旋区域。在多种病理状态下，中性粒细胞蛋白酶可能在体内胶原蛋白降解中起重要作用。
