[Increase in the concentration of alpha-fetoprotein in the blood of mice following a single dose of cyclophosphane].

Activation of extramedullar hemopoiesis in the liver together with an appreciable elevation of the alpha-fetoprotein (alpha-FP) level in the blood were observed in CBA, C3H/HeJ, DD, C57BL/6 and CC57BR/Mv mice after a single injection of cyclophosphane in a dose of 200 mg/kg bw. The alpha-FP concentration reached maximum days 2-4 after cyclophosphane administration, amounting of 290-560 ng/ml which surpasses 2-5-fold the basal level of the protein. In mice with an earlier serum alpha-FP elevation (CBA, C3H/HeJ and DD), the liver hemopoiesis also started earlier than in those with a delayed alpha-FP maximum (C57BL/6 and CC57BR/Mv).