Encabo H, Gioanni Y, Lamarche M
Electroencephalogr Clin Neurophysiol. 1981 Aug;52(2):127-39. doi: 10.1016/0013-4694(81)90160-7.
Mechanisms responsible for the triggering of paroxysmal events by proprioceptive afferents, previously described in the monkey with a chronic epileptic focus, were studied in more detail in the cat with a penicillin focus. To analyse the topical organization of this reflex triggering, the focus was restricted to very small areas of the motor cortex; in this study only pericruciate areas were considered in which stimulation elicited a motor response in one of the several forelimb muscles tested, and which received afferents from that muscle. When the focus was located in the post-sigmoid gyrus, stimulation (usually by stretch) of the given (target) muscle first elicited a cortical spike following the evoked response, and secondly a late phasic EMG response (about 40 msec latency) quite distinct from purely spinal reflexes. Cortical spikes and late EMG responses were closely correlated, especially considering their probability of occurrence or their parallel latency fluctuations. In most cases, this effect was limited to the muscle whose motor area had been treated with penicillin: stretching muscles in the vicinity was ineffective, nor were these muscles activated when the target muscle was stimulated. Evidence is given for the participation of a transcortical reflex in the generation of the late phasic response and for the involvement of the pyramidal tract in this reflex.
以前在患有慢性癫痫病灶的猴子身上描述过的，由本体感受传入神经触发阵发性事件的机制，在患有青霉素病灶的猫身上进行了更详细的研究。为了分析这种反射触发的局部组织，将病灶限制在运动皮层的非常小的区域；在这项研究中，仅考虑中央沟周围区域，在该区域刺激会在测试的几块前肢肌肉之一中引发运动反应，并且该区域接受来自该肌肉的传入神经。当病灶位于乙状结肠后回时，对给定（目标）肌肉的刺激（通常通过拉伸）首先在诱发反应后引发皮层棘波，其次是与纯脊髓反射非常不同的晚期相位肌电图反应（潜伏期约40毫秒）。皮层棘波和晚期肌电图反应密切相关，特别是考虑到它们的发生概率或平行的潜伏期波动。在大多数情况下，这种效应仅限于其运动区用青霉素处理过的肌肉：拉伸附近的肌肉无效，当刺激目标肌肉时这些肌肉也不会被激活。有证据表明，经皮层反射参与了晚期相位反应的产生，并且锥体束参与了这种反射。
