Bobáková E, Kosutzký J, Adamec O
Vet Med (Praha). 1981 Jun;26(6):379-84.
Hens were treated with three types of lipophil xenobiotics - polychlorinated biphenyl (PCB), lindane and hexachlorobenzene (HCB) - to study changes in the levels of microsomal proteins and in the activity of microsomal aryl 4-monooxygenase in liver. The above foreign substances were given in feed at a dose of 50 mg per kg during a fortnight. The level of microsomal proteins in liver increased after seven-day administration of xenobiotics and was always higher in the course of the experiment than in the controls. The activity of the microsomal enzyme (aryl 4-monooxygenase) was significantly higher in treated hens after seven- and 14-day interval, and also seven days after the end of feeding the contaminated feed mixture. Inductive properties were strongest in polychlorinated biphenyl (Delor 103), but lindane and hexachlorobenzene also induced a statistically significant rise, in comparison with the controls. It is shown that the inductive ability of lipophil xenobiotics is stronger in hens than in chicks, which may influence the metabolism of some biologically important substances in poultry organism.
用三种亲脂性外源性物质——多氯联苯（PCB）、林丹和六氯苯（HCB）——处理母鸡，以研究肝脏微粒体蛋白水平和微粒体芳基4-单加氧酶活性的变化。在两周内，以每千克50毫克的剂量将上述外来物质添加到饲料中。在给予外源性物质七天后，肝脏中微粒体蛋白水平升高，并且在实验过程中始终高于对照组。在间隔七天和十四天后，以及在停止喂食受污染饲料混合物七天后，经处理的母鸡体内微粒体酶（芳基4-单加氧酶）的活性显著更高。多氯联苯（Delor 103）的诱导特性最强，但与对照组相比，林丹和六氯苯也引起了统计学上的显著升高。结果表明，亲脂性外源性物质在母鸡中的诱导能力比在雏鸡中更强，这可能会影响家禽体内某些生物重要物质的代谢。
