Magro A M
Immunology. 1981 Sep;44(1):1-10.
Histamine release from the peritoneal mast cells of the Fawn-hooded rat strain is not potentiated by phosphatidylserine (PS) or lysophosphatidylserine (Lyso-PS). When compared with Wistar rats the Fawn-hooded rats produce normal levels of IgE. Except for not being potentiated, the mast cells of Fawn-hooded rats release histamine similarly to Wistar rats when challenged with a variety of IgE and non-IgE mediated inducing agents. Mast cells of Fawn-hooded rats, however, do not respond significantly to dextran challenge which is not improved by PS of Lyso-PS. In the absence of PS the Ca2+ dependence of release from the Fawn-hooded mast cells is similar to the Wistar strain and both are similarly altered in their Ca2+ dependence by the presence of PS; with PS the mast cells of both rat strains release maximum percentages of histamine at levels of Ca2+ which are inhibitory in the absence of PS. The kinetics of release is similar in the two strains. However, when the mast cells are challenged with inducing agent in the absence of Ca2+ the rate of desensitization is slowed by PS in the Wistar strain but not the Fawn-hooded strain.
磷脂酰丝氨酸（PS）或溶血磷脂酰丝氨酸（Lyso-PS）不会增强淡褐 hooded 大鼠品系腹膜肥大细胞的组胺释放。与 Wistar 大鼠相比，淡褐 hooded 大鼠产生正常水平的 IgE。除了不会被增强外，当用多种 IgE 和非 IgE 介导的诱导剂刺激时，淡褐 hooded 大鼠的肥大细胞释放组胺的方式与 Wistar 大鼠相似。然而，淡褐 hooded 大鼠的肥大细胞对右旋糖酐刺激没有明显反应，PS 或 Lyso-PS 也无法改善这种情况。在没有 PS 的情况下，淡褐 hooded 肥大细胞释放的 Ca2+依赖性与 Wistar 品系相似，并且在有 PS 的情况下，它们的 Ca2+依赖性都会以类似的方式改变；有 PS 时，两种大鼠品系的肥大细胞在 Ca2+水平下释放组胺的最大百分比，而在没有 PS 时这些 Ca2+水平是抑制性的。两种品系的释放动力学相似。然而，当在没有 Ca2+的情况下用诱导剂刺激肥大细胞时，Wistar 品系中 PS 会减缓脱敏速率，但淡褐 hooded 品系不会。
