注射干扰素诱导剂的小鼠发生的低血糖并非由干扰素介导。
Hypoglycemia in mice injected with interferon inducers is not mediated by interferon.
作者信息
Vignaux F, Gresser I
出版信息
Infect Immun. 1981 Aug;33(2):331-7. doi: 10.1128/iai.33.2.331-337.1981.
Abstract
Injection of mice with several viral and nonviral inducers of interferon resulted in a marked hypoglycemia. Interferon is not responsible for this effect since inoculation of a potent antiserum to interferon (which neutralized the endogenous interferon) did not prevent hypoglycemia and administration of potent interferon preparations did not lower blood sugar. Hypoglycemia induced by Newcastle disease virus and polyriboinosinic-polyribocytidylic acid was further exacerbated by injection of insulin.
摘要
给小鼠注射几种病毒和非病毒干扰素诱导剂会导致明显的低血糖。干扰素并非造成这种效应的原因，因为接种强效抗干扰素血清（可中和内源性干扰素）并不能预防低血糖，而给予强效干扰素制剂也不会降低血糖。新城疫病毒和聚肌苷酸 - 聚胞苷酸诱导的低血糖会因注射胰岛素而进一步加剧。
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本文引用的文献
1
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Infect Immun. 1971 Mar;3(3):444-8. doi: 10.1128/iai.3.3.444-448.1971.
2
PATTERNS OF INTERFERON APPEARANCE IN MICE INFECTED WITH BACTERIA OR BACTERIAL ENDOTOXIN.感染细菌或细菌内毒素的小鼠体内干扰素出现的模式
Nature. 1964 Nov 14;204:712. doi: 10.1038/204712a0.
3
Effects of bacterial endotoxin on metabolism. I. Carbohydrate depletion and the protective role of cortisone.细菌内毒素对代谢的影响。I. 碳水化合物消耗及可的松的保护作用。
J Exp Med. 1959 Sep 1;110(3):389-405. doi: 10.1084/jem.110.3.389.
4
Local Shwartzman phenomenon in athymic nude mice.无胸腺裸鼠的局部施瓦茨曼现象。
Proc Soc Exp Biol Med. 1980 May;164(1):75-81.
5
Inhibition of inducible liver enzymes by endotoxin and actinomycin D.内毒素和放线菌素D对诱导性肝酶的抑制作用。
J Bacteriol. 1966 Jul;92(1):107-15. doi: 10.1128/jb.92.1.107-115.1966.
6
Paths of carbon in gluconeogenesis and lipogenesis. IV. Inhibition by L-tryptophan of hepatic gluconeogenesis at the level of phosphoenolpyruvate formation.
J Biol Chem. 1966 Sep 10;241(17):3904-8.
7
Interferon activity associated with high molecular weight proteins in the circulation of mice injected with endotoxin or bacteria.与注射内毒素或细菌的小鼠血液循环中高分子量蛋白质相关的干扰素活性。
Virology. 1965 Nov;27(3):429-31. doi: 10.1016/0042-6822(65)90124-8.
8
Hypoglycemic activity of endotoxin. II. Mechanism of the phenomenon in BCG-infected mice.内毒素的降血糖活性。II. 卡介苗感染小鼠中该现象的机制。
J Bacteriol. 1969 May;98(2):494-501. doi: 10.1128/jb.98.2.494-501.1969.
9
Toxic properties of a synthetic double-stranded RNA. Endotoxin-like properties of poly I. poly C, an interferon stimulator.一种合成双链RNA的毒性特性。聚肌苷酸-聚胞苷酸（一种干扰素刺激剂）的类内毒素特性。
Nature. 1969 Aug 16;223(5207):715-7. doi: 10.1038/223715a0.
10
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Nature. 1969 Aug 16;223(5207):718. doi: 10.1038/223718a0.
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