Hellström I, Hellström K E
Int J Cancer. 1981;27(4):487-91. doi: 10.1002/ijc.2910270411.
In vitro studies were performed to search for cells in the thymus of BALB/c mice with MCA-induced sarcomas which could suppress either a secondary immune response to MuLV-associated tumor antigens present on a Moloney leukemia virus-induced lymphoma, LSTRA, or a primary cytotoxic response to C57BL/6 alloantigens. They showed that thymocytes from mice with sarcomas were suppressive in both systems, and that suppression was independent of whether or not the sarcomas expressed MuLV antigen gp70. Furthermore, normal thymocytes, when combined with mitomycin-C-treated cells from any of several different MCA-induced sarcomas, suppressed the in vitro generation of a secondary cytolytic response to LSTRA. We postulate that exposure of mice to certain tumor antigens induces cells which, in the presence of the same tumor antigens which are not detectably present on the tumor cells inducing the response.
进行了体外研究，以在BALB/c小鼠的胸腺中寻找具有MCA诱导肉瘤的细胞，这些细胞可以抑制对存在于莫洛尼白血病病毒诱导的淋巴瘤LSTRA上的MuLV相关肿瘤抗原的二次免疫反应，或抑制对C57BL/6同种异体抗原的初次细胞毒性反应。研究表明，患有肉瘤的小鼠的胸腺细胞在这两个系统中均具有抑制作用，并且这种抑制作用与肉瘤是否表达MuLV抗原gp70无关。此外，正常胸腺细胞与来自几种不同的MCA诱导肉瘤中任何一种的丝裂霉素-C处理细胞结合后，会抑制体外对LSTRA产生的二次溶细胞反应。我们推测，小鼠暴露于某些肿瘤抗原会诱导产生细胞，这些细胞在存在相同肿瘤抗原的情况下，而这些肿瘤抗原在诱导反应的肿瘤细胞上无法检测到。
