El-Salhy M, Grimelius L
Histochemistry. 1981;72(2):237-47. doi: 10.1007/BF00517137.
The endocrine pancreas of the grass lizard, Mabuya quinquetaenia-ta, and of the desert lizard, Uromastyx aegyptia, was investigated histologically and immunohistochemically. In both lizard species four cell types were observed in the endocrine pancreas, namely insulin (B), glucagon (A), somatostatin (D) and pancreatic polypeptide (PP) cells. In both species in B, A and D cells could be detected by their cross-reactivity with antisera raised against mammalian insulin, glucagon and somatostatin. However, these cells showed different tinctorial propertis in the two lizard species. In both species the endocrine tissues were concentrated in the splenic lobe of the pancreas. In the grass lizard the endocrine tissue in the splenic lobe of consisted mainly of B, A and D cells and in the ventral lobe the major cell types were PP and D cells. In the desert lizard, on the other hand, the frequency and the pattern of orientation of B, A and D cells were the same in both the splenic and the ventral lobes, but PP cells in the ventral lobe outnumbered those of the splenic lobe. The PP and D cells scattered in the exocrine parenchyma and the long protrusions which they exhibited suggested that these cell exerted paracrine control on the acinar cells. It is speculated that this control by PP cells may be trophic and by D cells inhibitory.
对草蜥（Mabuya quinquetaeniata）和沙漠蜥蜴（Uromastyx aegyptia）的内分泌胰腺进行了组织学和免疫组织化学研究。在这两种蜥蜴中，在内分泌胰腺中均观察到四种细胞类型，即胰岛素（B）、胰高血糖素（A）、生长抑素（D）和胰多肽（PP）细胞。在这两个物种中，B、A和D细胞可通过与针对哺乳动物胰岛素、胰高血糖素和生长抑素产生的抗血清的交叉反应性来检测。然而，这些细胞在两种蜥蜴物种中表现出不同的染色特性。在这两个物种中，内分泌组织都集中在胰腺的脾叶。在草蜥中，脾叶的内分泌组织主要由B、A和D细胞组成，而腹叶的主要细胞类型是PP和D细胞。另一方面，在沙漠蜥蜴中，脾叶和腹叶中B、A和D细胞的频率和排列模式相同，但腹叶中的PP细胞数量超过脾叶中的PP细胞。PP和D细胞分散在外分泌实质中，它们表现出的长突起表明这些细胞对腺泡细胞发挥旁分泌控制作用。据推测，PP细胞的这种控制可能是营养性的，而D细胞的控制是抑制性的。
