Vitvitski L, Trepo C, Hantz O
J Virol Methods. 1980;1(3):149-56. doi: 10.1016/0166-0934(80)90011-7.
The morphological similarities between B and non-A, non-B hepatitis viruses prompted the search for common antigenic determinants between the two agents. Major antigenic cross-reactivity was demonstrated by immunodiffusion between hepatitis B e/3 and the most common circulating antigen previously reported in the serum of patients with non-A, non-B hepatitis. Since it is the equivalent of an e antigen, this antigen will be hereafter referred to as non-A, non-B/e antigen. Screening with hepatitis B e/3 antigen or anti-hepatitis B e/3 by immunodiffusion may be used as an easy and efficient way to test for non-A, non-B hepatitis in the absence of specific reagents since it detected up to 91% of non-A, non-B antigen and 86% of anti-non-A, non-B/e. Antigenic cross-reactivity may be used to look for additional viruses belonging to the hepatitis B group.
B型肝炎病毒与非甲非乙型肝炎病毒之间的形态学相似性促使人们寻找这两种病原体之间的共同抗原决定簇。通过免疫扩散法证实，乙型肝炎e/3抗原与先前在非甲非乙型肝炎患者血清中报道的最常见循环抗原之间存在主要的抗原交叉反应。由于该抗原等同于e抗原，此后将其称为非甲非乙型/e抗原。在缺乏特异性试剂的情况下，用乙型肝炎e/3抗原或抗乙型肝炎e/3进行免疫扩散筛查，可作为一种简便有效的检测非甲非乙型肝炎的方法，因为它能检测出高达91%的非甲非乙型抗原和86%的抗非甲非乙型/e抗体。抗原交叉反应可用于寻找属于乙型肝炎组的其他病毒。
