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九种肽在大鼠脊髓中的分布,特别着重于胶状质和中央管周围区域(X层)。

The distribution of nine peptides in rat spinal cord with special emphasis on the substantia gelatinosa and on the area around the central canal (lamina X).

作者信息

Gibson S J, Polak J M, Bloom S R, Wall P D

出版信息

J Comp Neurol. 1981 Sep 1;201(1):65-79. doi: 10.1002/cne.902010106.

DOI:10.1002/cne.902010106
PMID:6168670
Abstract

The comparative distribution of nine peptides was examined in the L4 segment of the rat cord using the peroxidase antiperoxidase technique. The peptides examined were substance P, neurotensin, cholecystokinin, methionine-enkephalin, oxytocin, neurophysin, adrenocorticotrophin, thyrotropin releasing hormone, and vasoactive intestinal polypeptide. No transport blocking agents were used and in spite of this cell bodies containing substance P, neurotensin, cholecystokinin, and methionine-enkephalin were observed. All peptides except for thyrotropin releasing hormone were observed in fibers in laminae I and II. All peptides were present in the area around the central canal, lamina X. Each peptide had its own characteristic distribution within fibers in the gray and white matter.

摘要

运用过氧化物酶抗过氧化物酶技术,研究了九种肽在大鼠脊髓L4节段中的比较分布情况。所检测的肽包括P物质、神经降压素、胆囊收缩素、甲硫氨酸脑啡肽、催产素、神经垂体素、促肾上腺皮质激素、促甲状腺激素释放激素和血管活性肠肽。未使用转运阻断剂,尽管如此,仍观察到含有P物质、神经降压素、胆囊收缩素和甲硫氨酸脑啡肽的细胞体。除促甲状腺激素释放激素外,在I层和II层的纤维中均观察到所有肽。所有肽均存在于中央管周围区域(X层)。每种肽在灰质和白质的纤维中都有其自身的特征性分布。

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