Sinha T K, Queener S F, Bell N H, Larson S
Acta Endocrinol (Copenh). 1976 Oct;83(2):321-3. doi: 10.1530/acta.0.0830321.
Studies are presented in a patient with pseudohypoparathyroidism who showed a partial response to parathyroid extract. Resistance to the extract was observed after its short-term administration for the gourth time. Serum from the patient contained antibodies of the gamma G globulin class which bound 125I-labelled bovine parathyroid hormone. Prior incubation of parathyroid hormone with the serum prevented the activation in vitro of adenylate cyclase from pork renal cortex. The antibodies were directed primarily toward the C-terminal portion of the molecule. Thus, clinical resistance to parathyroid hormone is attributed to specific antibodies.
本文报道了一例假性甲状旁腺功能减退患者，该患者对甲状旁腺提取物有部分反应。在第四次短期给予提取物后，观察到对提取物产生了抵抗。患者血清中含有γG球蛋白类抗体，该抗体可结合125I标记的牛甲状旁腺激素。甲状旁腺激素与血清预先孵育可阻止猪肾皮质腺苷酸环化酶在体外的激活。这些抗体主要针对该分子的C末端部分。因此，临床对甲状旁腺激素的抵抗归因于特异性抗体。
