Avoli M, Siatitsas I, Kostopoulos G, Gloor P
Electroencephalogr Clin Neurophysiol. 1981 Oct;52(4):372-4. doi: 10.1016/0013-4694(81)90066-3.
The effects of post-ictal depression on spike and wave (SW) discharges of feline generalized penicillin epilepsy (FGPE) were studied. After tonic-clonic seizures which are not uncommon in FGPE spindle bursts appeared during the post-ictal period. Upon recovery spontaneous and thalamically evoked SW discharges reappeared. Spindles before penicillin and during post-ictal depression showed a similar intraburst frequency (twice that of SW discharges) in the same animal. These findings add further evidence to the notion that any depression of cortical excitability in FGPE leads to replacement of SW by spindles and thus supports the hypothesis that SW discharges occur in hyperexcitable cortex in response to normally spindle-inducing thalamocortical volleys.
研究了发作后抑郁对猫全身性青霉素癫痫（FGPE）棘波和慢波（SW）放电的影响。在FGPE中并不罕见的强直阵挛发作后，发作后期出现纺锤波爆发。恢复后，自发和丘脑诱发的SW放电再次出现。在同一动物中，青霉素注射前和发作后抑郁期间的纺锤波在爆发内频率相似（是SW放电频率的两倍）。这些发现进一步证明了FGPE中任何皮质兴奋性的降低都会导致纺锤波取代SW这一观点，从而支持了SW放电发生在皮质过度兴奋状态下以响应正常诱导纺锤波的丘脑皮质冲动这一假说。
