Uribe M
Rev Gastroenterol Mex. 1977 Jan-Apr;42(1):2-8.
Bioavailability is a term used to indicate measurement of both, the relative amount of and administered drug that reaches the general circulation and the rate at which this occurs. Assessment of bioavailability indeally requires specific and sensitive methods for determination of drug concentrations in human body fluids. For the purposes of most bioavailability studies, it is sufficient to determine four indexes: maximum drug serum concentrations (Cmax), time of maximum drug concentration (tCmax) area under the drug serum half life of the drug. Potential drugs interactions and the effect of the disease state must also be evaluated, to adjust drug dosage in order to obtain an optimal therapeutic effect with minimal unwanted side effects.
生物利用度是一个用于表示测量进入体循环的给药药物的相对量及其发生速率的术语。理想情况下，生物利用度评估需要用于测定人体体液中药物浓度的特定且灵敏的方法。对于大多数生物利用度研究而言，测定四个指标就足够了：药物血清最大浓度（Cmax）、最大药物浓度出现时间（tCmax）、药物血清半衰期的药物浓度-时间曲线下面积。还必须评估潜在的药物相互作用以及疾病状态的影响，以便调整药物剂量，从而在副作用最小的情况下获得最佳治疗效果。
