Studies on an interferon-sensitive mutant of mengovirus: effects on host RNA and protein syntheses.
作者信息
Fout G S, Simon E H
出版信息
J Gen Virol. 1981 Feb;52(Pt 2):391-4. doi: 10.1099/0022-1317-52-2-391.
PMID:6169788
Abstract
Interferon induces an activity which strongly inhibits the growth of is-1, an interferon-response mutant of mengovirus. This activity is not expressed in protected cells infected with either is+ (the wild-type parent) or vaccinia virus, or in cells infected with is-1 in the presence of actinomycin D. A failure of is-1 to shut off host RNA and/or protein synthesis could explain these observations. The present paper, however, shows that is-1 and is+ are equally effective in suppressing host synthesis, and suggests that is+ actively inhibits the interferon-mediated activity directed against is-1.
摘要
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