Abel E L, Dintcheff B A, Bush R
Neurobehav Toxicol Teratol. 1981 Fall;3(3):339-42.
Pregnant rats were intubated with beer, wine, whiskey, or ethanol (3 g/kg/day), twice daily, while control animals received an isocaloric solution. All animals were pair-fed to ethanol-treated animals. At birth, offspring were fostered to surrogate nondrug-treated dams. Congeners present in beverage alcohol did not exacerbate the effects of ethanol exposure. Ethanol-treated animals were less responsive than controls to a challenge dose of ethanol. Beer- and whiskey-treated animals were also less responsive than controls to ethanol challenge, but did not differ from ethanol-treated animals. Group differeces in Rotarod behavior, ambulation, rearing, or defecation in the activity box, activity wheel running, spontaneous alternation, and brain DNA, RNA, and protein content were not significant. Although beer-treated males performed better on the Rotarod than controls, beer-treated males did not differ significantly from controls on any other task.
给怀孕大鼠每日两次经插管给予啤酒、葡萄酒、威士忌或乙醇（3克/千克/天），而对照动物给予等热量溶液。所有动物与接受乙醇处理的动物配对饲养。出生时，将后代寄养给未接受药物处理的代孕母鼠。饮料酒精中的同系物不会加剧乙醇暴露的影响。接受乙醇处理的动物对乙醇激发剂量的反应比对照组小。接受啤酒和威士忌处理的动物对乙醇激发的反应也比对照组小，但与接受乙醇处理的动物没有差异。在旋转棒行为、活动箱中的行走、竖毛或排便、活动轮奔跑、自发交替以及脑DNA、RNA和蛋白质含量方面，组间差异不显著。尽管接受啤酒处理的雄性大鼠在旋转棒上的表现优于对照组，但在任何其他任务上，接受啤酒处理的雄性大鼠与对照组没有显著差异。
