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[与壳核和尾状核病变相关的失语型语言障碍:1例临床病理研究(作者译)]

[Aphasic-type language disorders associated with lesions of the putamen and caudate nucleus: clinicopathological findings in one case (author's transl)].

作者信息

Barat M, Mazaux J M, Bioulac B, Giroire J M, Vital C, Arné L

出版信息

Rev Neurol (Paris). 1981;137(5):343-56.

PMID:6170104
Abstract

Language disorders developed in a patient following a subcortical infarct involving the left putamen and caudate nucleus. Language was abundant and fluent, with many perseverations, semantic and ideation incoherences, and all activities concerned with verbal or non-verbal expression were affected. Lesions were present in the head and body of the caudate nucleus, the whole of the putamen, the anterior nucleus of the thalamus and the superior part of the internal capsule. The disorder was unique in relation to disturbances of the aphasic type observed in extensive thalamic lesions, or in transcortical sensorial aphasia. Physiopathological interpretation is based on the functional role of the putamen-caudate system in the regulation of many types of behaviour: animal experiments and results of applying stimuli in humans suggests a release of the inhibition exerted by the caudate nucleus on the frontal cortex. Lack of comparable clinicopathological data implies that other similar cases must be reported before the specificity of the disorder can be confirmed.

摘要

一名患者在发生涉及左侧壳核和尾状核的皮质下梗死之后出现了语言障碍。语言丰富且流畅,但存在许多持续言语、语义和思维连贯性障碍,并且所有与言语或非言语表达相关的活动均受到影响。病变位于尾状核的头部和体部、整个壳核、丘脑前核以及内囊上部。该障碍与在广泛丘脑病变或经皮质感觉性失语中观察到的失语类型的障碍有所不同。生理病理学解释基于壳核 - 尾状核系统在多种行为调节中的功能作用:动物实验以及在人体施加刺激的结果表明,尾状核对额叶皮质施加的抑制作用被解除。缺乏可比的临床病理数据意味着在能够确认该障碍的特异性之前,必须报告其他类似病例。

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