Dannevig B H, Tolleshaug H, Berg T
Biochim Biophys Acta. 1981 Nov 5;677(3-4):501-5. doi: 10.1016/0304-4165(81)90265-8.
125I-labelled asialofetuin injected intravenously into chars (Salmo alpinus L.) was cleared from the blood with a half-time of approx. 60 min. The injected asialofetuin was found to be accumulating in the liver when different organs were dissected out at various time points after the injection. 125I-labelled fetuin was not concentrated in the liver, and the uptake of 125I-labelled asialofetuin was almost completely inhibited by simultaneously injecting an excess unlabelled asialofetuin, indicating a specific uptake mechanism for the galactose-terminated glycoprotein in char liver. Denatured human serum albumin was not taken up by the liver, but was recovered in the kidneys, suggesting that the liver in char is devoid of macrophages. It therefore seems reasonable to assume that the injected 125I-labelled asialofetuin is taken up by the parenchymal cells of the char liver.
将125I标记的去唾液酸胎球蛋白静脉注射到嘉鱼（Salmo alpinus L.）体内后，其从血液中清除的半衰期约为60分钟。在注射后的不同时间点解剖出不同器官时，发现注射的去唾液酸胎球蛋白在肝脏中蓄积。125I标记的胎球蛋白没有在肝脏中聚集，同时注射过量未标记的去唾液酸胎球蛋白几乎完全抑制了125I标记的去唾液酸胎球蛋白的摄取，这表明嘉鱼肝脏中存在针对半乳糖末端糖蛋白的特异性摄取机制。变性的人血清白蛋白未被肝脏摄取，而是在肾脏中被回收，这表明嘉鱼的肝脏中没有巨噬细胞。因此，似乎有理由假设注射的125I标记的去唾液酸胎球蛋白被嘉鱼肝脏的实质细胞摄取。
