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人类补体成分C4拟硫酯键周围的氨基酸序列及其与C3和α2-巨球蛋白相应序列的比较。

Amino acid sequence around the proposed thiolester bond of human complement component C4 and comparison with the corresponding sequences from C3 and alpha 2-macroglobulin.

作者信息

Campbell R D, Gagnon J, Porter R R

出版信息

Biosci Rep. 1981 May;1(5):423-9. doi: 10.1007/BF01116192.

DOI:10.1007/BF01116192
PMID:6170355
Abstract

The amino acid sequence around the proposed thiolester bond in human complement component C4 has been determined. The sulphydryl and reactive acyl groups involved in the intrachain thiolester bond are contained in a short section of sequence which shows almost complete identity with the equivalent sequence from alpha 2-macroglobulin and C3. Other regions of homology between the three proteins near the proposed thiolester bond are also apparent.

摘要

已确定人补体成分C4中拟议的硫酯键周围的氨基酸序列。链内硫酯键所涉及的巯基和反应性酰基包含在一段短序列中，该序列与α2-巨球蛋白和C3的等效序列几乎完全相同。在拟议的硫酯键附近，这三种蛋白质之间的其他同源区域也很明显。

相似文献

1
Amino acid sequence around the proposed thiolester bond of human complement component C4 and comparison with the corresponding sequences from C3 and alpha 2-macroglobulin.人类补体成分C4拟硫酯键周围的氨基酸序列及其与C3和α2-巨球蛋白相应序列的比较。
Biosci Rep. 1981 May;1(5):423-9. doi: 10.1007/BF01116192.
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引用本文的文献

1
Sequence determination of the thiolester site of the fourth component of human complement.人补体第四成分硫酯位点的序列测定
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7388-92. doi: 10.1073/pnas.78.12.7388.
2
MHC Class III products: an electron microscopic study of the C3 convertases of human complement.主要组织相容性复合体III类产物：人类补体C3转化酶的电子显微镜研究
J Exp Med. 1984 Jan 1;159(1):324-9. doi: 10.1084/jem.159.1.324.
3
The beta-Cys-gamma-Glu thiolester bond in human C3, C4, and alpha 2-macroglobulin.人补体C3、C4和α2-巨球蛋白中的β-半胱氨酸-γ-谷氨酸硫酯键。
Springer Semin Immunopathol. 1983;6(4):259-82. doi: 10.1007/BF02116276.
4
Evolution of alpha 2-macroglobulin. The structure of a protein homologous with human alpha 2-macroglobulin from plaice (Pleuronectes platessa L.) plasma.α2-巨球蛋白的进化。来自鲽（欧洲鲽）血浆的与人α2-巨球蛋白同源的一种蛋白质的结构。
Biochem J. 1982 Jul 1;205(1):105-15. doi: 10.1042/bj2050105.
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Third component of human complement: localization of the internal thiolester bond.人类补体的第三成分：内部硫酯键的定位
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1054-8. doi: 10.1073/pnas.79.4.1054.
6
Amino acid sequence of the trypsin-generated C3d fragment from human complement factor C3.人补体因子C3经胰蛋白酶消化产生的C3d片段的氨基酸序列。
Biochem J. 1985 Sep 1;230(2):353-61. doi: 10.1042/bj2300353.
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Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement.香烟烟雾可通过修饰补体第三成分在体外激活补体替代途径。
J Clin Invest. 1985 Mar;75(3):1000-7. doi: 10.1172/JCI111760.
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The low C5 convertase activity of the C4A6 allotype of human complement component C4.人类补体成分C4的C4A6同种异型的低C5转化酶活性。
Biochem J. 1989 Aug 1;261(3):743-8. doi: 10.1042/bj2610743.