Apuzzo M L, Weiss M H, Minassian H V
Bull Los Angeles Neurol Soc. 1977 Jul;42(2):63-70.
We have treated a selected series of patients with spinal epidural metastatic tumors by dorsal decompression according to principles we presumed would produce the most favorable therapeutic results. There was no operative mortality, and morbidity was minor. In the first postoperative week, improvement in motor function was apparent in 44% of cases. By 3 months postoperatively, 40% of the patients were independently ambulatory and an additional 28% were ambulatory with minimal assistance. This 68% composite compares favorably to the 30 to 40% results in several series of unselected cases. On the basis of this data, it is concluded that consideration of the tumor's histological type, biological history, the host's response, the extent of neurological deficit, the progression of neurological deficit, and dissemination of disease will aid in the definition of those cases with epidural metastases which may be expected to benefit from surgical decompression.
我们根据自认为能产生最有利治疗效果的原则,对一系列经挑选的脊髓硬膜外转移瘤患者进行了后路减压治疗。无手术死亡病例,发病率较低。术后第一周,44%的病例运动功能有明显改善。术后3个月时,40%的患者能够独立行走,另有28%的患者在极少帮助下能够行走。这68%的综合结果与几组未经挑选病例中30%至40%的结果相比更具优势。基于这些数据,得出结论:考虑肿瘤的组织学类型、生物学史、宿主反应、神经功能缺损程度、神经功能缺损进展情况以及疾病播散情况,将有助于明确那些可能有望从手术减压中获益的硬膜外转移病例。