Ojo-Amaize E A, Salimonu L S, Williams A I, Akinwolere O A, Shabo R, Alm G V, Wigzell H
J Immunol. 1981 Dec;127(6):2296-300.
Natural killer (NK) cell activity and interferon levels have been measured in the peripheral blood of children acutely ill with Plasmodium falciparum infection. The NK cell levels were found to be raised in the malaria-infected children, with a positive correlation between the degree of parasitemia and lytic activity. Comparatively high titers of antiviral activity was discovered in sera from the majority of P. falciparum-infected children, again positively correlating with the degree of parasitemia and NK levels. The characteristics of the antiviral factor indicated alpha-type interferon to be the dominating agent involved. Addition of exogenous interferon in vitro potentiated the NK levels of PBL from normal children while having no significant impact on cells from malaria-infected children.
已对急性感染恶性疟原虫的儿童外周血中的自然杀伤（NK）细胞活性和干扰素水平进行了检测。发现疟疾感染儿童的NK细胞水平升高，寄生虫血症程度与裂解活性之间呈正相关。在大多数恶性疟原虫感染儿童的血清中发现了相对较高滴度的抗病毒活性，同样与寄生虫血症程度和NK水平呈正相关。抗病毒因子的特征表明α型干扰素是主要的相关因子。体外添加外源性干扰素可增强正常儿童外周血淋巴细胞（PBL）的NK水平，而对疟疾感染儿童的细胞无显著影响。
