Floersheim G L, Torhorst J
Oncology. 1981;38(6):321-8. doi: 10.1159/000225581.
The growth of a syngeneic Moloney lymphoma in CBA mice was inhibited by the injection of lymph node cells from normal CBA donors. This cytotherapeutic effect was also seen after chemotherapy with cyclophosphamide (CY) or dimethylmyleran (DMM). Two other murine tumours, the Meth A sarcoma in Balb/c mice and the L1210 leukemia in BDF1 mice, did not respond to treatment with normal syngeneic cells. In the L1210 system, tumour-promoting effects of fetal liver cells were demonstrated. The tumour inhibitory effects of normal lymph node cells against the Moloney lymphoma may be a virus-dependent phenomenon mediated through interferon and natural killer' cells. The experiments also showed the sensitivity of the Moloney lymphoma and the Meth A sarcoma to CY and DMM and the responsiveness of the L1210 leukemia to AAFC.
将正常CBA供体的淋巴结细胞注射到CBA小鼠体内，可抑制同基因莫洛尼淋巴瘤的生长。在使用环磷酰胺（CY）或二甲苯磺酸丁酯（DMM）进行化疗后，也观察到了这种细胞治疗效果。另外两种小鼠肿瘤，即Balb/c小鼠的Meth A肉瘤和BDF1小鼠的L1210白血病，对同基因正常细胞治疗无反应。在L1210系统中，证明了胎肝细胞具有肿瘤促进作用。正常淋巴结细胞对莫洛尼淋巴瘤的肿瘤抑制作用可能是一种通过干扰素和自然杀伤细胞介导的病毒依赖性现象。实验还表明，莫洛尼淋巴瘤和Meth A肉瘤对CY和DMM敏感，L1210白血病对AAFC有反应。
