Tarquini B, Halberg F, Seal U S, Benvenuti M, Cagnoni M
Prostate. 1981;2(3):269-79. doi: 10.1002/pros.2990020305.
Bromocriptine mesylate lowers the serum concentration of prolactin and TSH in patients with prostatic hypertrophy as a function of drug administration time. The effect of a 2.5-mg dose in lowering these two hormones in presumably similar patients is statistically highly significant and relatively large at unusual test times (in the evening); at other, conventional test or administration times (early morning or midday), it is smaller, questionable, or not demonstrable with the dose and conditions used. Dosing without timing may lead to reduced effect or lack of effect, ambiguity and controversy, and lack of timing may account for the circumstance that an effect of bromocriptine upon TSH in human serum was not previously established. Rigorous assessment of the effect of bromocriptine mesylate upon circulating TSH and prolactin requires consideration of the entire spectrum of rhythms, ultradian and infradian as well as circannual. The circadian approach here analyzed represents a step toward that goal and indicates that the circadian frequency is a critical determinant of this response. Manipulation of TSH concentration in serum, in turn, is of interest in view of the demonstrated alteration of the circannual TSH rhythm in patients with prostatic cancer.
甲磺酸溴隐亭可降低前列腺肥大患者血清催乳素和促甲状腺激素（TSH）的浓度，其降低作用与给药时间有关。在推测病情相似的患者中，2.5毫克剂量在不寻常的检测时间（晚上）降低这两种激素的效果在统计学上具有高度显著性且相对较大；在其他常规检测或给药时间（清晨或中午），使用该剂量和条件时，效果较小、存疑或无法显示。不考虑给药时间可能导致效果降低或无效、结果含糊和存在争议，而缺乏给药时间考虑可能是此前未证实溴隐亭对人血清TSH有作用的原因。要严格评估甲磺酸溴隐亭对循环TSH和催乳素的作用，需要考虑各种节律，包括超日节律、次昼夜节律以及年节律。本文分析的昼夜节律方法是朝着这一目标迈出的一步，表明昼夜节律频率是该反应的关键决定因素。鉴于已证实前列腺癌患者的年TSH节律发生改变，血清TSH浓度的调控也因此受到关注。
