[Gamma globulin as a prophylactic measure in an outbreak of hepatitis A in an institution for mentally retarded children (author's transl)].

An outbreak of hepatitis A was observed in an institution for mentally handicapped children. Within 2 months 21 cases occurred in 4 out of 7 groups. By means of gamma-globulin administration and measures of general hygiene, the outbreak, although not immediately stopped, was brought under control. The number of overt cases was reduced and further transmission to 3 other groups was prevented. The detection of IgM antibodies to hepatitis A virus proved to be very suitable for diagnostic purposes. Subsequently it turned out that the gamma-globulin used had a very low titre in comparison with other preparations. Recommendations are given to prevent similar outbreaks in the future.