Essman E J, Essman W B, Valderrama E
Arch Dermatol Res. 1981;271(3):325-40. doi: 10.1007/BF00409461.
The topical application of sodium fluoride to abraded rat skin produced several morphological and biochemical effects. Related to the degranulation of dermal mast cells, skin histamine concentration was increased, fluorides were absorbed into the skin, and deposited mainly kin mitochondria. Dermal histamine binding was decreased for both H1 and H2 receptors with reduced binding sites, but epidermal adenyl cyclase was activated by fluorides. The response of the rat skin to fluorides involves a sequence of changes by which the potentiation of an inflammatory response also involves alterations in specific histamine receptors and a histamine-specific adenyl cyclase system.
将氟化钠局部应用于擦伤的大鼠皮肤会产生多种形态学和生物化学效应。与真皮肥大细胞脱颗粒相关，皮肤组胺浓度升高，氟化物被吸收进入皮肤，并主要沉积在线粒体中。H1和H2受体的皮肤组胺结合均减少，结合位点减少，但表皮腺苷酸环化酶被氟化物激活。大鼠皮肤对氟化物的反应涉及一系列变化，炎症反应的增强也涉及特定组胺受体和组胺特异性腺苷酸环化酶系统的改变。
